Gene information
Official symbol FLT1
Official full name fms related receptor tyrosine kinase 1
Gene type protein-coding gene
Chromosome13q12.3
Alias symbolVEGFR1
Previous symbolFLT
Gene familyReceptor tyrosine kinases; I-set domain containing
Resources
Entrez Gene 2321
HGNC HGNC:3763
Ensembl ENSG00000102755
Vega OTTHUMG00000016648
UCSC uc001usb.4
GO terms: 75 records
GO Description Category LogP Number of genes Detail
GO:0001525 angiogenesis GO Biological Processes -32.8794581 74 More
GO:0001568 blood vessel development GO Biological Processes -43.2646440 106 More
GO:0001934 positive regulation of protein phosphorylation GO Biological Processes -52.8272623 84 More
GO:0001936 regulation of endothelial cell proliferation GO Biological Processes -54.5504306 75 More
GO:0001944 vasculature development GO Biological Processes -42.3240404 107 More
GO:0002244 hematopoietic progenitor cell differentiation GO Biological Processes -2.29650667 5 More
GO:0002520 immune system development GO Biological Processes -15.2957169 80 More
GO:0002548 monocyte chemotaxis GO Biological Processes -10.9439631 11 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007167 enzyme-linked receptor protein signaling pathway GO Biological Processes -26.8285253 93 More
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway GO Biological Processes -16.7048742 60 More
GO:0008285 negative regulation of cell population proliferation GO Biological Processes -53.5569125 147 More
GO:0010517 regulation of phospholipase activity GO Biological Processes -7.06832255 9 More
GO:0010518 positive regulation of phospholipase activity GO Biological Processes -7.78358420 9 More
GO:0010863 positive regulation of phospholipase C activity GO Biological Processes -6.38368268 7 More
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -15.9250248 30 More
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO Biological Processes -18.2876323 28 More
GO:0015629 actin cytoskeleton GO Cellular Components -8.47641494 26 More
GO:0016301 kinase activity GO Molecular Functions -2.42130611 19 More
GO:0019199 transmembrane receptor protein kinase activity GO Molecular Functions -5.31743835 14 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019838 growth factor binding GO Molecular Functions -18.6841278 23 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030097 hemopoiesis GO Biological Processes -14.1443585 71 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0030595 leukocyte chemotaxis GO Biological Processes -30.6401488 33 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035924 cellular response to vascular endothelial growth factor stimulus GO Biological Processes -8.07167727 14 More
GO:0038084 vascular endothelial growth factor signaling pathway GO Biological Processes -6.53278734 9 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0043235 receptor complex GO Cellular Components -19.4198369 40 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043406 positive regulation of MAP kinase activity GO Biological Processes -13.8261343 18 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043410 positive regulation of MAPK cascade GO Biological Processes -49.4744054 112 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0043550 regulation of lipid kinase activity GO Biological Processes -3.76907414 6 More
GO:0043551 regulation of phosphatidylinositol 3-kinase activity GO Biological Processes -3.24021630 5 More
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity GO Biological Processes -4.38579065 5 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045766 positive regulation of angiogenesis GO Biological Processes -39.3444092 63 More
GO:0045834 positive regulation of lipid metabolic process GO Biological Processes -24.1838255 28 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045860 positive regulation of protein kinase activity GO Biological Processes -29.3929160 47 More
GO:0048010 vascular endothelial growth factor receptor signaling pathway GO Biological Processes -5.65848894 6 More
GO:0048514 blood vessel morphogenesis GO Biological Processes -39.8784810 93 More
GO:0048534 hematopoietic or lymphoid organ development GO Biological Processes -16.4041704 79 More
GO:0048598 embryonic morphogenesis GO Biological Processes -22.1253699 83 More
GO:0048880 sensory system development GO Biological Processes -3.47450215 31 More
GO:0050678 regulation of epithelial cell proliferation GO Biological Processes -51.9930445 102 More
GO:0050680 negative regulation of epithelial cell proliferation GO Biological Processes -26.5961536 48 More
GO:0050900 leukocyte migration GO Biological Processes -39.9164759 46 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0060191 regulation of lipase activity GO Biological Processes -10.2745708 13 More
GO:0060193 positive regulation of lipase activity GO Biological Processes -9.32996784 11 More
GO:0060326 cell chemotaxis GO Biological Processes -35.3882493 41 More
GO:0070848 response to growth factor GO Biological Processes -40.6139195 102 More
GO:0071363 cellular response to growth factor stimulus GO Biological Processes -39.8883675 98 More
GO:0071674 mononuclear cell migration GO Biological Processes -16.6998600 20 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0071902 positive regulation of protein serine/threonine kinase activity GO Biological Processes -13.5008002 23 More
GO:0090218 positive regulation of lipid kinase activity GO Biological Processes -5.34310134 6 More
GO:0097529 myeloid leukocyte migration GO Biological Processes -25.8454617 28 More
GO:0150063 visual system development GO Biological Processes -3.59465978 31 More
GO:1900274 regulation of phospholipase C activity GO Biological Processes -6.23203613 7 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1904018 positive regulation of vasculature development GO Biological Processes -39.3444092 63 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
KEGG pathways: 9 records
KEGG Description Category LogP Number of genes Detail
hsa04010 MAPK signaling pathway KEGG Pathway -13.6331973 26 More
hsa04014 Ras signaling pathway KEGG Pathway -9.01898803 33 More
hsa04015 Rap1 signaling pathway KEGG Pathway -8.52596130 17 More
hsa04020 Calcium signaling pathway KEGG Pathway -10.4415222 36 More
hsa04066 HIF-1 signaling pathway KEGG Pathway -20.6790877 23 More
hsa04151 PI3K-Akt signaling pathway KEGG Pathway -29.3006421 73 More
hsa04510 Focal adhesion KEGG Pathway -16.5268196 41 More
hsa05202 Transcriptional misregulation in cancer KEGG Pathway -9.99536642 18 More
hsa05323 Rheumatoid arthritis KEGG Pathway -22.3868189 23 More
Drug-Gene interaction
view
Related drugs: 80 records
Drug name Interaction type Source PMID View
4sc-203 inhibitor ChemblInteractions view
abicipar pegol TdgClinicalTrial view
aee-788 inhibitor ChemblInteractions view
ag-13958 inhibitor ChemblInteractions view
alisertib DTC view
ast-487 DTC view
axitinib inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractionsCancerCommonsMyCancerGenomeClinicalTrialPharmGKB 2012495118541897 view
azd-1152-hqpa DTC view
bms-690514 inhibitor ChemblInteractions view
brivanib inhibitor ChemblInteractions view
brivanib alaninate inhibitor ChemblInteractions view
cediranib inhibitor TALCDTCTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsCancerCommons view
cenisertib DTC view
cep-11981 inhibitor ChemblInteractionsTTD view
cep-5214 inhibitor DTCChemblInteractions 14640546 view
cep-7055 inhibitor ChemblInteractions view
chembl1997335 DTC view
chiauranib inhibitor ChemblInteractions view
cp-459632 inhibitor ChemblInteractions view
cyc-116 DTC view
doramapimod DTC view
dovitinib inhibitor DTCTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsCancerCommons view
enmd-2076 inhibitor MyCancerGenome view
entrectinib DTC view
erlotinib DTC view
famitinib inhibitor ChemblInteractionsTTD view
foretinib inhibitor MyCancerGenomeChemblInteractions view
fruquintinib inhibitor TdgClinicalTrialChemblInteractionsTTD view
glesatinib inhibitor TALCMyCancerGenomeTdgClinicalTrial view
go-6976 DTC view
gw843682x DTC view
icrucumab antagonist ChemblInteractions view
ilorasertib inhibitor DTCChemblInteractions view
jnj-7706621 DTC view
kenpaullone DTC view
krn-633 inhibitor ChemblInteractions view
l-21649 inhibitor ChemblInteractions view
lenvatinib inhibitor TALCTdgClinicalTrial 17943726 view
lenvatinib mesylate inhibitor ChemblInteractions view
linifanib inhibitor DTCMyCancerGenomeTdgClinicalTrialChemblInteractions view
lucitanib inhibitor ChemblInteractionsMyCancerGenomeClinicalTrial view
mgcd-265 inhibitor ChemblInteractions view
motesanib inhibitor TALCMyCancerGenomeTdgClinicalTrialChemblInteractionsPharmGKB 20124951 view
muparfostat TdgClinicalTrial view
nintedanib inhibitor TALCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrial 1855952431016670 view
nintedanib esylate inhibitor ChemblInteractions view
orantinib inhibitor MyCancerGenome view
osi-632 DTC view
osi-930 inhibitor ChemblInteractions view
pazopanib inhibitor TALCDTCMyCancerGenomeTdgClinicalTrialMyCancerGenomeClinicalTrial 17288876 view
pazopanib hydrochloride inhibitor ChemblInteractions view
pd-0166285 DTC view
pegpleranib sodium TdgClinicalTrial view
pf-00562271 DTC view
r-406 DTC view
rabeprazole sodium inhibitor MyCancerGenomeTTD view
regorafenib inhibitor TALCMyCancerGenomeChemblInteractionsMyCancerGenomeClinicalTrial view
rg-1530 inhibitor DTCChemblInteractions view
semaxanib inhibitor ChemblInteractions view
sorafenib inhibitor DTCMyCancerGenomeMyCancerGenomeClinicalTrialPharmGKB 17016424283627161546620616507829 view
sorafenib tosylate inhibitor ChemblInteractions view
sp-600125 DTC view
su-014813 inhibitor ChemblInteractions view
sunitinib inhibitor TALCDTCTdgClinicalTrialTENDMyCancerGenomeClinicalTrialPharmGKB 2147803619248971269359272358391117367763201249512408673614654525 view
sunitinib malate inhibitor ChemblInteractions view
surufatinib inhibitor ChemblInteractionsTTD view
tae-684 DTC view
tak-593 inhibitor ChemblInteractions view
telatinib TdgClinicalTrial view
telbermin agonist ChemblInteractions view
tesevatinib inhibitor MyCancerGenomeTdgClinicalTrial view
tg100-801 inhibitor ChemblInteractions view
tivozanib inhibitor TALCMyCancerGenomeTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsTTD view
tozasertib DTC view
vandetanib inhibitor DTCTdgClinicalTrialClearityFoundationClinicalTrialChemblInteractionsMyCancerGenomeClinicalTrial view
vatalanib inhibitor TALCDTCMyCancerGenomeTdgClinicalTrialChemblInteractions 17584317 view
vegfrecine DTC view
x-82 inhibitor MyCancerGenomeChemblInteractionsTTD view
xl-820 inhibitor ChemblInteractions view
xl-999 inhibitor ChemblInteractions view
Related studies: 8 records
Molecular factor Omics type Application Objective MI type Reference
vascular endothelial growth factor receptor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Kodama Y et al. J Am Coll Cardiol. 2006
vascular endothelial growth factor receptor 1 proteomics atorvastatin[treatment (pharmacotherapy)] acute myocardial infarction Kodama Y et al. J Am Coll Cardiol. 2006
vascular endothelial growth factor receptor 1 proteomics medium predictor acute myocardial infarction[diagnosis] acute myocardial infarction Hochholzer W et al. Eur Heart J. 2011
vascular endothelial growth factor receptor 1 proteomics death[prognosis (bad)] acute myocardial infarction Hochholzer W et al. Eur Heart J. 2011
vascular endothelial growth factor receptor 1 proteomics acute myocardial infarction[diagnosis] acute myocardial infarction Liebetrau C et al. Heart. 2014
NC_000013.11:g.28399484G>A genomics myocardial infarction[diagnosis] myocardial infarction Matsuoka R et al. Int J Mol Med. 2015
vascular endothelial growth factor receptor 1 proteomics acute heart failure[prognosis (bad)] acute ST elevation myocardial infarction Onoue K et al. Am J Cardiol. 2009
vascular endothelial growth factor receptor 1 proteomics poor predictor acute type 4a myocardial infarction[diagnosis] acute type 4a myocardial infarction Searle J et al. Biomarkers. 2012
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